Liquisolid systems as a novel approach in formulation and manufacturing of solid dosage forms: Challenges and perspectives

Liquisolid systems are a novel, promising platform for the production of solid dosage forms with high liquid content, i.e. dispersion drug in suitable, hydrophilic, non-volatile vehicle or drug. This technology requires conventional, but highly porous excipients (carrier and coating material appropriate ratio) able to absorb/adsorb medication, resulting both good flowability acceptable compression properties. approach has shown great potential improve dissolution rate bioavailability poorly soluble drugs, been recognized as alternative common, more complex expensive techniques. A variety applications this simple technique have investigated recently, including preparation of: modified release tablets, orally disintegrating herbal extracts, etc. emerging numerous advantages, most important are: simplicity, cost-effectiveness, applicability large scale environmental friendliness. However, it is accompanied by certain challenges well, such limited case dosed drugs. article aims give comprehensive overview recent progress regarding technology, well an insight into new liquisolid-based techniques intending further support its commercial applicability.